Fourteen years ago, Dr. Karl Matthews, head of Government Biolab 83, is savagely murdered by ancient soul-taker, MR. HELL. Today, Dr. Matthews' daughter, Tyler, has returned to the scene of her father's death. Unknown to Tyler, MR. HELL has also returned. To complicate this house of horrors, a group of mercenaries has invaded the lab to steal a deadly vial of bacterium. Many will soon suffer grisly deaths, along with having their eyes(the windows to the soul)harvested by MR. HELL.

The scientist Diana Purlow is performing experiments with the mind of criminals sentenced to death in the prison of the sadistic warden Earl Blakely. She tests an apparatus she developed and capable of read minds in a man that claims to be innocent of a murder, but she is not able to convince her former lover and Governor to call off the execution. When the serial killer Jesse Mowatt is arrested and sentenced to death, she convinces the warden to submit Jesse to her experiment. While working with the murderer, Diana faces pure evil in its essence.